Pesquisa | BVS Odontologia

1.

Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles.

Sunazuka, Yushi; Ueda, Keisuke; Higashi, Kenjirou; Wada, Koichi; Moribe, Kunikazu.

Mol Pharm ; 21(3): 1424-1435, 2024 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-38324797

2.

Controlled Sublimation Rate of Guest Drug from Polymorphic Forms of a Cyclodextrin-Based Polypseudorotaxane Complex and Its Correlation with Molecular Dynamics as Probed by Solid-State NMR.

Kundu, Sudeshna; Higashi, Kenjirou; Takamizawa, Makoto; Ueda, Keisuke; Limwikrant, Waree; Yamamoto, Keiji; Moribe, Kunikazu.

Mol Pharm ; 21(3): 1501-1514, 2024 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-38363209

3.

Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities.

Ueda, Keisuke; Higashi, Kenjirou; Moribe, Kunikazu.

Mol Pharm ; 20(4): 1861-1871, 2023 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-36939575

4.

Transition from Amorphous Cyclosporin A Nanoparticles to Size-Reduced Stable Nanocrystals in a Poloxamer 407 Solution.

Chen, Ziqiao; Higashi, Kenjirou; Ueda, Keisuke; Moribe, Kunikazu.

Mol Pharm ; 19(1): 188-199, 2022 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-34843257

5.

Variable-Temperature NMR Analysis of the Thermodynamics of Polymer Partitioning between Aqueous and Drug-Rich Phases and Its Significance for Amorphous Formulations.

Ueda, Keisuke; Higashi, Kenjirou; Moribe, Kunikazu; Taylor, Lynne S.

Mol Pharm ; 19(1): 100-114, 2022 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-34702040

6.

Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency.

Morita, Takeshi; Mukaide, Sayaka; Chen, Ziqiao; Higashi, Kenjirou; Imamura, Hiroshi; Moribe, Kunikazu; Sumi, Tomonari.

Nano Lett ; 21(3): 1303-1310, 2021 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-33480258

7.

Nanostructure and Molecular-Level Characterization of Aminoalkyl Methacrylate Copolymer and the Impact on Drug Solubilization Ability.

Okamoto, Yuta; Higashi, Kenjirou; Morita, Takeshi; Ueda, Keisuke; Mukaide, Sayaka; Takeda, Junpei; Karashima, Masatoshi; Ikeda, Yukihiro; Moribe, Kunikazu.

Mol Pharm ; 18(11): 4111-4121, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-34641686

8.

Molecular Mobility Suppression of Ibuprofen-Rich Amorphous Nanodroplets by HPMC Revealed by NMR Relaxometry and Its Significance with Respect to Crystallization Inhibition.

Ueda, Keisuke; Yamamoto, Neo; Higashi, Kenjirou; Moribe, Kunikazu.

Mol Pharm ; 16(12): 4968-4977, 2019 12 02.

Artigo em Inglês | MEDLINE | ID: mdl-31661287

9.

Effect of Drug-Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance.

Ishizuka, Yuya; Ueda, Keisuke; Okada, Hitomi; Takeda, Junpei; Karashima, Masatoshi; Yazawa, Koji; Higashi, Kenjirou; Kawakami, Kohsaku; Ikeda, Yukihiro; Moribe, Kunikazu.

Mol Pharm ; 16(6): 2785-2794, 2019 06 03.

Artigo em Inglês | MEDLINE | ID: mdl-31045376

10.

Intermolecular Interactions between Drugs and Aminoalkyl Methacrylate Copolymer in Solution to Enhance the Concentration of Poorly Water-Soluble Drugs.

Higashi, Kenjirou; Ueda, Keisuke; Moribe, Kunikazu.

Chem Pharm Bull (Tokyo) ; 67(9): 906-914, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31474728

11.

Mechanism of Enhanced Nifedipine Dissolution by Polymer-Blended Solid Dispersion through Molecular-Level Characterization.

Ueda, Keisuke; Yamazoe, Chisato; Yasuda, Yuki; Higashi, Kenjirou; Kawakami, Kohsaku; Moribe, Kunikazu.

Mol Pharm ; 15(9): 4099-4109, 2018 09 04.

Artigo em Inglês | MEDLINE | ID: mdl-30064220

12.

Morphological and Physicochemical Evaluation of Two Distinct Glibenclamide/Hypromellose Amorphous Nanoparticles Prepared by the Antisolvent Method.

Yonashiro, Hazuki; Higashi, Kenjirou; Morikawa, Chikako; Ueda, Keisuke; Itoh, Tsutomu; Ito, Masataka; Masu, Hyuma; Noguchi, Shuji; Moribe, Kunikazu.

Mol Pharm ; 15(4): 1587-1597, 2018 04 02.

Artigo em Inglês | MEDLINE | ID: mdl-29502422

13.

DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy.

Kawai, Minori; Nakamura, Takashi; Miura, Naoya; Maeta, Mio; Tanaka, Hiroki; Ueda, Keisuke; Higashi, Kenjirou; Moribe, Kunikazu; Tange, Kota; Nakai, Yuta; Yoshioka, Hiroki; Harashima, Hideyoshi; Akita, Hidetaka.

Nanomedicine ; 14(8): 2587-2597, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30170077

14.

An Insight into Stabilization Mechanism of a Solid Dispersion of Indomethacin/Partially Hydrolyzed Polyvinyl Alcohol Prepared by Hot-Melt Extrusion.

Benjasirimongkol, Porntip; Ueda, Keisuke; Higashi, Kenjirou; Sriamornsak, Pornsak; Moribe, Kunikazu.

Chem Pharm Bull (Tokyo) ; 66(9): 859-865, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30175742

15.

Direct NMR Monitoring of Phase Separation Behavior of Highly Supersaturated Nifedipine Solution Stabilized with Hypromellose Derivatives.

Ueda, Keisuke; Higashi, Kenjirou; Moribe, Kunikazu.

Mol Pharm ; 14(7): 2314-2322, 2017 07 03.

Artigo em Inglês | MEDLINE | ID: mdl-28558250

16.

Application of Solid-State NMR Relaxometry for Characterization and Formulation Optimization of Grinding-Induced Drug Nanoparticle.

Ueda, Keisuke; Higashi, Kenjirou; Moribe, Kunikazu.

Mol Pharm ; 13(3): 852-62, 2016 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-26855230

17.

Direct evaluation of molecular States of piroxicam/poloxamer nanosuspension by suspended-state NMR and Raman spectroscopies.

Hasegawa, Yuki; Higashi, Kenjirou; Yamamoto, Keiji; Moribe, Kunikazu.

Mol Pharm ; 12(5): 1564-72, 2015 May 04.

Artigo em Inglês | MEDLINE | ID: mdl-25849345

18.

Insights into atomic-level interaction between mefenamic acid and eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy.

Higashi, Kenjirou; Yamamoto, Kazutoshi; Pandey, Manoj Kumar; Mroue, Kamal H; Moribe, Kunikazu; Yamamoto, Keiji; Ramamoorthy, Ayyalusamy.

Mol Pharm ; 11(1): 351-7, 2014 Jan 06.

Artigo em Inglês | MEDLINE | ID: mdl-24283196

19.

Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids.

Chen, Ziqiao; Higashi, Kenjirou; Shigehisa, Yuki; Ueda, Keisuke; Yamamoto, Keiji; Moribe, Kunikazu.

Nanoscale ; 15(6): 2602-2613, 2023 Feb 09.

Artigo em Inglês | MEDLINE | ID: mdl-36484313

20.

Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles.

Hanada, Naho; Higashi, Kenjirou; Zhao, Zhijing; Ueda, Keisuke; Moribe, Kunikazu.

Int J Pharm ; 640: 122959, 2023 Jun 10.

Artigo em Inglês | MEDLINE | ID: mdl-37086931

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Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles.

Controlled Sublimation Rate of Guest Drug from Polymorphic Forms of a Cyclodextrin-Based Polypseudorotaxane Complex and Its Correlation with Molecular Dynamics as Probed by Solid-State NMR.

Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities.

Transition from Amorphous Cyclosporin A Nanoparticles to Size-Reduced Stable Nanocrystals in a Poloxamer 407 Solution.

Variable-Temperature NMR Analysis of the Thermodynamics of Polymer Partitioning between Aqueous and Drug-Rich Phases and Its Significance for Amorphous Formulations.

Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency.

Nanostructure and Molecular-Level Characterization of Aminoalkyl Methacrylate Copolymer and the Impact on Drug Solubilization Ability.

Molecular Mobility Suppression of Ibuprofen-Rich Amorphous Nanodroplets by HPMC Revealed by NMR Relaxometry and Its Significance with Respect to Crystallization Inhibition.

Effect of Drug-Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance.

Intermolecular Interactions between Drugs and Aminoalkyl Methacrylate Copolymer in Solution to Enhance the Concentration of Poorly Water-Soluble Drugs.

Mechanism of Enhanced Nifedipine Dissolution by Polymer-Blended Solid Dispersion through Molecular-Level Characterization.

Morphological and Physicochemical Evaluation of Two Distinct Glibenclamide/Hypromellose Amorphous Nanoparticles Prepared by the Antisolvent Method.

DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy.

An Insight into Stabilization Mechanism of a Solid Dispersion of Indomethacin/Partially Hydrolyzed Polyvinyl Alcohol Prepared by Hot-Melt Extrusion.

Direct NMR Monitoring of Phase Separation Behavior of Highly Supersaturated Nifedipine Solution Stabilized with Hypromellose Derivatives.

Application of Solid-State NMR Relaxometry for Characterization and Formulation Optimization of Grinding-Induced Drug Nanoparticle.

Direct evaluation of molecular States of piroxicam/poloxamer nanosuspension by suspended-state NMR and Raman spectroscopies.

Insights into atomic-level interaction between mefenamic acid and eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy.

Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids.

Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles.